PharmaNest Presents NASH Digital Pathology and AI Results With a Performance That Compares to Histological Stages and Imaging Methods at the Liver Meeting® | AASLD 2022

PharmaNest, an emerging leader in quantitative Digital Pathology and Artificial Intelligence, showcases the utility and performance of its FibroNest continuous scores for the quantification of the treatment effects of NASH therapies at the 2022 Liver Meeting® | AASLD conference

FibroNest Ai Scores

PharmaNest, an emerging leader in quantitative Digital Pathology and Artificial Intelligence, announces today that it will present, alongside with its collaborators, three abstracts at this year's Liver Meeting | AASLD Conference, Nov. 4-8, 2022 in Washington, D.C. The abstracts highlight the utility and performance of FibroNest, the first multi-vendor quantitative digital Pathology image analysis and translational platform for the assessment of the severity and progression of Fibrosis and disease activity in NASH and Cirrhosis, and other fibrotic conditions.

"The automated quantification of the phenotype of fibrosis severity from the same slides reviewed by pathologists offers a robust and scalable method to generate continuous scores across the continuum of NAFLD, NASH and Cirrhosis. Thanks to its high detection thresholds, the FibroNest method can measure faint changes and specific traits of disease regression induced by candidate drugs," said Mathieu Petitjean, CEO and founder of PharmaNest. 

The first two abstracts are retrospective analysis of liver biopsies from the LiFT Phase 2 trial of LPCN1144 (NCT04134091). They show (i) how FibroNest's continuous fibrosis score detects drug effects that are missed by conventional histological methods and (ii) that the quantification of the anti-steatosis effect of LPCN1144 is similar whether using MRI-PDFF, FibroNest Steatosis scores, or histological steatosis grades (in partnership with Lipocine, Inc).

A third abstract describes the performance of the FibroNest fibrosis score along the Cirrhosis spectrum (N=100) and demonstrates how the phenotypic nature of this score reduces the intra-("geographic") coefficient of variability in liver biopsies from previously reported values of 47% down to 16% in average (in partnership with Mount Sinai University).

The specific details of these abstracts are available on PharmaNest website at

As a multi-vendor platform, FibroNest is compatible with all kinds of digital image formats including conventional digital pathology-stained slides (Picro Sirius Red, Trichrome or Antibody stains for fibrosis) acquired by FDA-approved digital pathology scanners and other digital microscopes. It is a Research-Use-Only tool for now.

Source: PharmaNest, Inc.


PharmaNest is an Artificial Intelligence and Digital Pathology company focused on the development and validation of novel standards for the quantification of the histological phenotypes Fibrosis at its associated features

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