Undersea and Hyperbaric Medicine Journal Has Published a Special Issue on TBI Studies
North Palm Beach, Florida, November 14, 2016 (Newswire.com) - The Undersea and Hyperbaric Medical Society (www.uhms.org) has published a supplemental issue of its member publication, the Undersea and Hyperbaric Medicine Journal, to summarize results and findings in baseline publications for studies on traumatic brain injury (TBI). The issue, consisting of 9 papers plus an executive summary, reports on the Brain Injury and Mechanisms of Action of Hyperbaric Oxygen (HBO2) for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) Study.
This special issue of the UHM Journal is available to the public at https://www.uhms.org/publications/uhm-journal/purchase-uhm-journal-v43-i5-in-pdf.html. Cost for the electronic copy is $25. UHMS members have free access to the PDF files.
The Undersea and Hyperbaric Medical Society ( www.uhms.org ) has published a supplemental issue of its member publication, the Undersea and Hyperbaric Medicine Journal, to summarize results and findings in baseline publications for studies on traumatic brain injury (TBI).
Renee Duncan for John Peters, Communications Coordinator for Executive Director
Sponsored by the Department of Defense and held under an investigational new drug application by the Office of the Army Surgeon General, the BIMA study is one of the largest and most complex clinical trials of hyperbaric oxygen (HBO2) for post-concussive symptoms (PCS) in U.S. military service members.
“Compared to previously published HBO2 trials for PCS, this randomized, double-blinded, sham-controlled exploratory study has a longer duration of follow-up and more comprehensive battery of assessments,” notes Dr. Lindell K. Weaver, study director and lead principal investigator.
The study looks at active-duty military and veteran personnel with mild TBI sustained while on active duty who remain symptomatic three months to five years later. Assessment tools include testing of vestibular, audiologic, neuropsychological, autonomic, neurological and ocular functions; neuroimaging; sleep studies; physical exams; and laboratory testing.
Primary objectives of the BIMA study are:
• to identify endpoints for future trials of potential treatments for PCS;
• to describe brain function and anatomy of the military population with PCS at baseline and across time; and
• to explore potential associations between changes in brain function, anatomy and participant-reported outcomes.
Secondary objectives are to evaluate safety of HBO2 and sham interventions and identify practical issues in instituting study assessments.
The study has identified outcomes that suggest baseline abnormality or deficit. “The outstanding adherence to interventions and study visit completion through 12 months positions the BIMA study to provide Class I evidence on the potential mechanisms of action of HBO2 as well as the properties of potential outcome measures for the design of future studies,” said Dr. Weaver, adding that several outcomes have been identified in these baseline publications that show as candidate outcomes for PCS. These will be the focus of further investigation following the close of the study.
“Having these BIMA specialty papers published will facilitate manuscript preparation immensely when study results become available,” said Dr. Weaver. As with all papers that appear in the UHM Journal, these TBI-related texts received peer review.
Study results of HBO2 vs. sham treatments in the BIMA study are not yet available. Notes UHM Journal Editor-in-Chief Dr. Enrico Camporesi, “We plan to follow with another issue discussing hyperbaric oxygen therapy trials for TBI in approximately a year.”
The print version has been mailed to subscribers. To subscribe, go to the tab 'Publications' on the UHMS website ( www.uhms.org ) and use the pull-down menu for 'Purchase UHM Journal Subscription.'
Here's listing of papers and authors in this issue.
Executive summary: The Brain Injury and Mechanism of Action of Hyperbaric
Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic
Brain Injury (mTBI) (BIMA) Study
LK Weaver, A Chhoeu, AS Lindblad, S Churchill, SH Wilson
Hyperbaric oxygen for mild traumatic brain injury: Design and baseline summary
LK Weaver, A Chhoeu, AS Lindblad, S Churchill, SH Wilson
Baseline neurological evaluations in a hyperbaric trial of post-concussive syndrome
CS Williams, LK Weaver, AS Lindblad, S Kumar, DR Langford
Baseline EEG abnormalities in mild traumatic brain injury from the BIMA study
CS Williams, MC Spitz, JF Foley, LK Weaver, AS Lindblad, MR Wierzbicki
Linear analysis of heart rate variability in post-concussive syndrome
S Mirow, SH Wilson, LK Weaver, S Churchill, K Deru, AS Lindblad
Sleep assessments for a mild traumatic brain injury trial in a military population
JM Walker, NT James, H Campbell, SH Wilson, S Churchill, LK Weaver
Baseline vestibular and auditory findings in a trial of post-concussive syndrome
A Meehan, E Searing, LK Weaver, A Lewandowski
Neuropsychological assessments in a hyperbaric trial of post-concussive symptoms
SH Wilson, LK Weaver, AS Lindblad
Hyperbaric oxygen for persistent post-concussive symptoms: long-term follow-up
LD Skipper, S Churchill, SH Wilson, K Deru, RJ Labutta, BB Hart
Review of recent non-hyperbaric oxygen interventions for mild traumatic brain injury
SH Wilson, M Rothe, AS Lindblad, LK Weaver
For more information, email uhms@uhms.org.
Source: Undersea and Hyperbaric Medical Society