CardioBiome Reviews 2026: Could This Once-Daily Gut-to-Heart Formula Be the Missing Piece in Your Cardiovascular Wellness Routine?

CAMAS, Wash., August 25, 2026 (Newswire.com) - Disclaimers: This is a paid advertorial, and a commission is earned if you buy through the links here. Claims about the product are attributed to the brand, not independently verified by this publication. CardioBiome™ is a dietary supplement, not an FDA-approved drug, and it's not meant to diagnose, treat, cure, or prevent any disease. This content is promotional in nature and is intended for consumer education regarding a commercially available product.

Official site: mysimplepromise.com/products/cardiobiome.

CardioBiome Consumer Research 2026: The 2-to-4x TMAO Claim Sounds Impressive - Here's What the Study Actually Found

TL;DR: CardioBiome™ pairs three probiotic strains (KABP®011, 012, 013) with 100 mg CoQ10 and 250 mg standardized artichoke extract in one daily capsule, priced at $ 33 to $ 49 per bottle with a 365-day guarantee. The brand's headline claim - a 2-to-4x TMAO reduction - is real, but it doesn't mean what the ad implies. Here's the actual study behind it.

You saw an ad for CardioBiome™, and the number that stuck was probably the 2-to-4x TMAO reduction - it's specific, it's science-sounding, and it's exactly the kind of number that makes an ad stand out from the rest of your feed. If that's what brought you here, that number deserves a closer look before it influences a buying decision. The study behind it is real. The full result is more specific than the headline makes it sound - and you're about to see exactly how.

This CardioBiome Review 2026 pulls apart the ingredients, the pricing, the guarantee, and - in more depth than most reviews bother with - the actual clinical study behind the KABP® strains, including exactly where that TMAO number comes from and who it really applies to. By the end you'll know enough to decide for yourself, no second article required.

Title phrases including "Gut-to-Heart" reflect Simple Promise's own marketing language at mysimplepromise.com. This publication does not independently substantiate them. Readers seeking verification context should continue reading.

What Is CardioBiome?

CardioBiome™ is a dietary supplement marketed by Simple Promise™, sold as a single daily capsule that focuses on three ingredients: a probiotic blend, CoQ10, and artichoke leaf extract. According to Simple Promise, the formula is centered on what the brand calls the "gut-heart connection" - the idea that gut bacteria, cholesterol metabolism, and cellular energy all belong in the same cardiovascular conversation, rather than being addressed by three separate supplements.

The brand describes CardioBiome™ as intended for adults who want to support cholesterol and blood pressure that are already within a normal range, as well as general cardiovascular energy. It is marketed and positioned as a dietary supplement, not a treatment for diagnosed heart disease, hypertension, or high cholesterol, and Simple Promise is explicit that it isn't a substitute for medical care. CardioBiome™ is marketed by Simple Promise™. Product formulation and manufacturing claims in this article are attributed to the brand; this publication's role is limited to independently researching and explaining publicly available information, not formulating or manufacturing the product.

See the formula and current pricing →

Who Is CardioBiome Built For?

For consumers comparing one-capsule formulas that combine KABP® probiotic strains, CoQ10, and artichoke extract, CardioBiome™ occupies a distinctive formulation niche. Based on the verified facts in this article, it's worth a closer look if you're:

• Specifically interested in the gut-microbiome angle on cardiovascular support, not just a standalone CoQ10 or artichoke supplement

• Looking for a single daily capsule instead of stacking two or three separate products

• Comfortable evaluating a formula backed by real but early-stage, small-sample human research, rather than a large randomized trial

• Someone who wants to see the underlying study before deciding, not just the marketing headline

• Looking for a longer-than-average refund window while you try it

It's a weaker fit if you were specifically drawn in by the TMAO claim as a general benefit - the research doesn't support that for most people, as the next section covers in detail - or if an established, multi-year review history matters to your decision, since none exists yet for this product.

CardioBiome Ingredients and Supplement Facts

Per the Supplement Facts panel published on the official product page, one CardioBiome™ capsule - the full daily serving - contains:

• Artichoke (Cynara scolymus) leaf extract - 250 mg

• Coenzyme Q10 (Ubiquinone) - 100 mg

• KABP® Metaguard Probiotic Blend - 50 mg total, containing Lactiplantibacillus plantarum KABP®011, KABP®012, and KABP®013

Those three numbers - 250 mg, 100 mg, 50 mg - are label facts, confirmed directly against the live Supplement Facts panel. That's a separate thing from what the brand says those ingredients do, and separate again from what independent research on those ingredients actually shows. It's worth keeping those three categories apart as you read the rest of this article:

• Label fact: what's on the Supplement Facts panel, verified directly.

• Brand-positioned benefit: what Simple Promise says the ingredient is included to do.

• Independent research: what a peer-reviewed study actually measured and found, checked against the brand's characterization rather than repeated uncritically.

The panel lists the three probiotic strains as a combined 50 mg blend rather than disclosing the amount of each strain separately. That means the exact milligram split among KABP®011, 012, and 013 isn't disclosed on the published label. Other ingredients are hydroxypropyl methylcellulose (a plant-based capsule shell), magnesium stearate, microcrystalline cellulose, and silicon dioxide. Simple Promise states the product is free of gluten, stimulants, caffeine, and sugar, and describes it as vegetarian-friendly and non-GMO. One bottle contains 30 capsules, a 30-day supply at the labeled one-capsule daily dose.

What Does the CardioBiome Clinical Study Actually Show?

This is the section that actually separates a useful CardioBiome review from a rewritten sales page, so it's worth slowing down for.

The primary research citation for CardioBiome's probiotic blend is a 2024 study published in Cardiovascular Research, the journal of the European Society of Cardiology (Padro et al.), testing the same three strains listed on CardioBiome's label as the branded formula AB-LIFE®.

• Strains tested: KABP011, KABP012, and KABP013 - the same three named on CardioBiome's label

• Participants: 20 healthy adults with overweight (10 men, 10 women, ages 25-60)

• Exclusions: no diagnosed cardiovascular disease, no lipid-lowering medication

• Design: single-arm, dose-escalating, four weeks, no placebo group

That last point matters: without a comparison group taking an inactive capsule, some of the observed changes could reflect factors other than the probiotic itself.

Within that design, the study measured several outcomes:

• Bile acids and cholesterol. Probiotic intake was associated with reductions in non-HDL and LDL cholesterol, with the largest effect in participants who had higher baseline LDL.

• ApoB48 and ApoB100. Fasting plasma levels of both markers decreased significantly during the intervention. A decrease in ApoB48 was observed in 19 of 20 participants on Days 14 and 28.

• LDL particle behavior. LDL particles showed reduced susceptibility to oxidation, and the number of small, dense LDL particles - considered more atherogenic than larger particles - decreased significantly.

• TMAO (trimethylamine N-oxide). This is the measurement CardioBiome's marketing highlights most prominently, and it's the one that needs the most careful reading - covered in full in the next section.

Two limitations are worth stating plainly, because CardioBiome's marketing doesn't emphasize them: this was a small study (20 participants) over a short window (four weeks), with no placebo control and no long-term follow-up. That's a legitimate, peer-reviewed starting point for the strain combination - not the kind of large, randomized, placebo-controlled trial that would let anyone call the cholesterol or ApoB findings settled science. It's also a study of the probiotic blend itself, not of the finished CardioBiome™ capsule, which combines that blend with CoQ10 and artichoke extract. No clinical trial of that finished three-ingredient combination was identified in the product materials or in the research reviewed for this article - the cited research instead concerns the probiotic strain combination and individual ingredients on their own.

CardioBiome and TMAO: What Buyers Should Understand

Does CardioBiome reduce TMAO? Based on the cited research, not in the way the marketing implies.

CardioBiome's product page states that "in a clinical study, KABP® strains supported a 2-to-4-fold reduction in TMAO over 28 days." That specific number is real and traceable to the Padro et al. 2024 study - but it doesn't describe what happened to the study group as a whole. Across all 20 participants, median TMAO levels were unchanged by the end of the four-week intervention. Most participants started with TMAO within the normal physiological range and remained there.

The 2-to-4-fold reduction applied specifically to two of the twenty participants - the two who entered the study with elevated baseline TMAO, above 15 µM, a level the researchers noted as being in a higher-risk range for cardiovascular concerns. For those two individuals, TMAO dropped substantially over the study period. For the other eighteen, TMAO stayed roughly where it started.

• Full study group (20 participants): no significant change in median TMAO

• Subgroup with elevated baseline TMAO (2 participants): 2-to-4-fold reduction over 28 days

• Remaining 18 participants: started in a normal range, stayed there

The cited study does not demonstrate a significant reduction in TMAO across the entire study population. The reported 2- to 4-fold reductions occurred in two participants who entered the study with elevated baseline TMAO levels. If TMAO is a specific concern for you - something typically flagged by a blood or urine test your doctor can order - that's a conversation to have directly with your physician, not a result this article or the brand's marketing can promise for your individual case.

See CardioBiome pricing next to the verified label →

Simple Promise cites CoQ10 research in two separate contexts, and they shouldn't be blended together. The larger citation is the Q-SYMBIO trial - a randomized, double-blind study of CoQ10 in heart-failure patients, independently verified for this article against the published trial data:

• Participants: 420 patients with moderate-to-severe chronic heart failure

• Design: randomized, double-blind, CoQ10 or placebo added to standard therapy, followed for two years

• Cardiovascular mortality: 9% (CoQ10) vs. 16% (placebo)

• All-cause mortality: 10% (CoQ10) vs. 18% (placebo)

That's a real, verified trial - and it's a study of a specific, sick patient population on top of standard heart-failure therapy, not a study of healthy adults taking a daily wellness capsule. This heart-failure trial should not be interpreted as a clinical trial of CardioBiome™ itself, nor does it mean CardioBiome™ reduces mortality, treats heart failure, or replaces any prescribed heart-failure medication.

Separately, the brand cites smaller research suggesting CoQ10 may support blood pressure already within a normal range. That's a more modest claim, backed by different and smaller studies than the Q-SYMBIO trial, and the two shouldn't be read as the same body of evidence.

CardioBiome Artichoke Extract Research

The artichoke leaf extract in CardioBiome™ is standardized to cynarin, the compound most associated with the plant's traditional use for digestive and liver support. Simple Promise cites research on cynarin's role in bile production and cholesterol metabolism, along with a randomized, placebo-controlled trial in adults with mild hypertension who took a concentrated artichoke leaf extract for 12 weeks, showing statistically significant reductions in both systolic and diastolic blood pressure compared to placebo. It's worth noting that the broader research picture on artichoke and blood pressure is mixed: at least one systematic review pooling multiple randomized trials found significant reductions in both readings, whereas a separate meta-analysis using a different set of trials found no significant pooled effect. Individual trials showing a benefit are real; the pooled evidence across the full body of research is not uniformly positive.

The same rule applies here as with CoQ10: that blood pressure trial tested artichoke extract on its own, in a population selected specifically for elevated blood pressure, not the finished CardioBiome™ capsule and not a general population with blood pressure already in a normal range. It's legitimate supporting research for the ingredient. It is not evidence that CardioBiome™ itself lowers blood pressure.

How to Take CardioBiome

Per the official product page:

• Dose: one capsule daily, taken in the morning with a glass of water

• Food timing: no specific rule stated

• Early effects: some users reportedly notice an energy change within 1-2 weeks

• Full effect window: the brand recommends 90 to 180 days of consistent daily use for full microbiome-support effects

This article isn't the place to get guidance on adjusting any prescribed cardiovascular medication - that conversation belongs with your prescribing doctor.

CardioBiome Price and Bundle Options

According to the Simple Promise product page reviewed in August 2026, CardioBiome™ is sold in three one-time-purchase tiers:

• 1 bottle: $49 (listed against an $89 brand-stated reference price)

• 3 bottles: $129 total, $43 per bottle (listed against a $267 brand-stated reference price)

• 6 bottles: $198 total, $33 per bottle (listed against a $534 brand-stated reference price)

The $89, $267, and $534 figures are brand-listed reference prices, not independently established retail values. Free shipping is stated for U.S. orders. No separate checkout fees beyond the listed bottle price were shown on the product page during the review for this article.

Lock in the $33-a-bottle six-pack rate →

Is CardioBiome a Subscription?

No. The accessible product and checkout materials reviewed showed the CardioBiome™ offer as a one-time purchase rather than an automatically recurring subscription, with no auto-shipments or recurring charges confirmed on the pages reviewed. Checkout flows can change, so it's worth confirming the purchase type shown at checkout before you complete an order.

CardioBiome Shipping

Per Simple Promise's shipping and returns FAQ:

• U.S. shipping: free, estimated 5-7 business days

• International shipping: carries a charge (exact amount not confirmed in this review), estimated 10-14 business days subject to customs

• Tracking: provided, through a carrier partner

• Possible delays: the brand notes supply-chain issues can occasionally add to delivery times

If you're ordering from outside the United States, confirm the exact shipping charge with Simple Promise support before checkout.

CardioBiome 365-Day Money-Back Guarantee

CardioBiome™ is backed by Simple Promise's 365-day money-back guarantee, described on the product page as "Love It or It's Free" and on the refund policy page as "iron-clad" and "unconditional."

• Window: 365 days from your order date

• Process: contact customer support within that year for a full refund

• Return-shipping payer, carrier, and tracking requirements: not specified on the accessible policy pages

• Processing time once a return is received: up to two weeks (up to 30 days or more internationally)

• Funds back to your card or bank: an additional 10-14 business days after processing

Given the window's length and mechanics, the return-shipping specifics are worth confirming directly with support before you order.

Are There CardioBiome Customer Reviews Yet?

Not at the time this article was researched. The CardioBiome™ product page showed zero customer reviews and included an on-page invitation to be the first to submit one. There's currently no independent or on-site review volume, positive or negative, to weigh alongside the brand's own claims. Simple Promise's broader site includes testimonials for other products, with a standard disclosure that names and images are changed for privacy and that individual results vary - but none of that testimonial history currently exists specifically for CardioBiome™.

CardioBiome Pros and Limitations

What can reasonably be counted as advantages, based on verified facts:

• Ingredient amounts are disclosed on the label rather than hidden behind a vague proprietary blend, aside from the individual strain split within the probiotic blend.

• The three named KABP® strains have been evaluated together in a published human study.

• Single-capsule daily format rather than a multi-pill regimen.

• The brand offers a 365-day money-back guarantee.

• Straightforward, disclosed bundle pricing with no subscription confirmed.

Limitations worth weighing before you order:

• The KABP® study is small (20 participants), short (4 weeks), and not placebo-controlled.

• No clinical trial of the finished CardioBiome™ capsule - the specific combination of probiotic blend, CoQ10, and artichoke extract - was identified in the product materials or research reviewed for this article; the cited research instead concerns the probiotic strain combination and individual ingredients.

• The marketed TMAO effect wasn't demonstrated across the full study group, only in a small subgroup with elevated baseline TMAO.

• Individual milligram amounts for each of the three probiotic strains within the 50 mg blend aren't disclosed.

• No customer review history exists yet for this specific product.

• Return-shipping mechanics under the guarantee, the exact international shipping charge, and the specific cGMP-certified facility aren't detailed on the accessible pages.

Is CardioBiome Legitimate?

Several material product details are publicly verifiable through Simple Promise's product materials and the cited research: a named, contactable brand with a public product page, a disclosed Supplement Facts panel, working customer service contact information, a published refund policy, and real peer-reviewed research supporting its named probiotic strains.

That verifiability does not independently establish that every advertised benefit will occur for every individual user. Being a real, identifiable company selling a disclosed product is a different question from whether the product will work for you personally - and this article is drawing that distinction on purpose, because the two get conflated constantly in this category.

Does CardioBiome Work?

Available evidence does not support a simple yes-or-no conclusion about the finished CardioBiome™ product. The formula contains ingredients and named probiotic strains with published, peer-reviewed research behind them, but the strength and relevance of that evidence varies by claim: the ApoB48 and LDL-oxidation findings were observed in the cited study, subject to the limitations of its small sample size, short duration, and single-arm design; the TMAO claim, as marketed, is not well-supported for the general population; and none of the underlying research tested the finished three-ingredient capsule as a combined product. Whether it "works" for your specific goals depends on which claim you're evaluating - which is why this article breaks the research apart by ingredient and by outcome instead of giving one blanket verdict.

See CardioBiome's current bundle tiers →

Is CardioBiome Safe? Side Effects and Medication Considerations

No independent safety trial of the finished CardioBiome™ product was found in the materials reviewed for this article, and this article does not claim the product is safe, free of side effects, or free of medication interactions for every user - those are claims nobody can responsibly make about any supplement without individualized medical evaluation. Simple Promise advises consumers taking blood pressure, cholesterol, or blood-thinning medications to consult a doctor or pharmacist before use. This article echoes that recommendation rather than attempting to assess medication compatibility for individual readers. If you're managing a diagnosed cardiovascular condition or taking prescription medication in any of those categories, that conversation with your prescriber should happen before you order.

CardioBiome vs. Other Heart Supplements

In terms of formula category, here's how CardioBiome™ differs structurally from other common heart-supplement types - factual formulation differences, not claims about which performs better:

• CardioBiome™: cardiovascular-marker-studied probiotic blend + CoQ10 + standardized artichoke extract, in one capsule

• A standard digestive probiotic: typically studied and marketed for gut outcomes rather than cardiovascular markers specifically

• A CoQ10-only supplement: delivers just that one ingredient, without the probiotic or artichoke components

No head-to-head data exists comparing CardioBiome™ against other named products.

Where to Buy CardioBiome

The official product and pricing information for CardioBiome™ lives on Simple Promise's own site. This article links to that offer through a tracked promotional link, with the commission relationship disclosed at the top of this page. Current pricing, bundle availability, and checkout terms can change, so it's worth confirming the details shown at checkout match what's described here.

Go to the official CardioBiome order page →

Things to Verify Before You Order

1. Individual strain amounts. The label lists the three KABP® strains as a combined 50 mg blend without an individual milligram breakdown.

2. cGMP certification specifics. The brand states the product is made in a cGMP-certified facility but doesn't name the facility or its location on the pages reviewed.

3. Return shipping terms. Who pays for return shipping and what carrier or tracking requirements apply to a refund request aren't stated on the refund policy page as published.

4. International shipping charge. Delivery windows are stated (5-7 days U.S., 10-14 days international), but the exact international shipping fee wasn't confirmed in the materials reviewed.

Fast Facts

• Brand: Simple Promise™, operated by Simple Promise Pte Ltd

• Product form: Capsule, 30 per bottle, one-month supply at labeled dose

• Serving size: 1 capsule daily

• Core ingredients: KABP® Metaguard Probiotic Blend (50 mg: KABP®011, 012, 013), CoQ10 (100 mg), Artichoke leaf extract (250 mg, standardized to cynarin)

• Price, 1 bottle: $49

• Price, 3 bottles: $129 ($43/bottle)

• Price, 6 bottles: $198 ($33/bottle)

• Shipping: Free U.S. (5-7 business days); international carries a charge (10-14 business days, customs-dependent)

• Guarantee: 365 days from order date; return-shipping mechanics unconfirmed

• Subscription: None confirmed - one-time purchase on accessible pages

• Dietary profile: Gluten-, stimulant-, caffeine-, and sugar-free; vegetarian-friendly; non-GMO, per the brand

• Reviews on file: None at time of review

• Primary clinical citation: Padro et al., Cardiovascular Research, 2024 - KABP011/012/013, 20 participants, 4 weeks, single-arm

• Phone support: 1-800-259-9522, stated as 24/7 in the brand's FAQ

• Email: support@mysimplepromise.com

• Mailing address: 3242 NE 3rd Avenue #1051, Camas, WA 98607

Quick Answers

What is CardioBiome?

A daily capsule dietary supplement from Simple Promise™ combining three probiotic strains, CoQ10, and artichoke leaf extract, marketed for cholesterol, blood pressure, and cardiovascular energy support.

How much does CardioBiome cost?

$49 for one bottle, dropping to $43 and $33 per bottle at three- and six-bottle quantities, per the official site as of August 2026.

Does CardioBiome reduce TMAO?

The cited study found no significant change in TMAO across the entire study group; a 2- to 4-fold reduction was observed only in the two participants with elevated baseline TMAO.

Is CardioBiome FDA approved?

No. CardioBiome™ is marketed as a dietary supplement, not an FDA-approved drug. Dietary supplements are not FDA pre-approved before sale.

How to Read CardioBiome's Marketing Language

The phrase "Gut-to-Heart" used in this article's title and throughout Simple Promise's marketing is the brand's own coined positioning language, not an independently validated clinical classification. Phrases like "steady heart, steady numbers" and "valuable ally in cardiovascular health" are similarly brand-originated marketing language describing intended positioning, not measured outcomes verified by this publication.

Frequently Asked Questions

What is CardioBiome?

CardioBiome™ is a dietary supplement from Simple Promise™, taken as one capsule daily, combining a three-strain probiotic blend with CoQ10 and artichoke leaf extract. It's marketed for cardiovascular support from what the brand calls a gut-heart angle, positioned for adults focused on cholesterol and blood pressure already in a normal range, as well as general cardiovascular energy.

What are the CardioBiome ingredients?

Per the Supplement Facts panel: 250 mg artichoke leaf extract standardized to cynarin, 100 mg CoQ10, and a 50 mg KABP® Metaguard Probiotic Blend containing three L. plantarum strains - KABP®011, 012, and 013. Individual strain amounts within the blend aren't broken out separately on the label.

How much does CardioBiome cost?

One bottle is $49. Pricing drops to $43 per bottle at three bottles ($129 total) and $33 per bottle at six bottles ($198 total), per the official product page reviewed in August 2026. The brand's listed $89/$267/$534 reference prices are brand-stated comparison points, not independently verified retail values.

Does CardioBiome reduce TMAO?

Not across the board, based on the cited research. The clinical study behind the KABP® strains found that TMAO levels were essentially unchanged for the study group overall; the 2- to 4-fold reduction cited in CardioBiome's marketing occurred specifically in the two participants who started with elevated baseline TMAO.

What is KABP Metaguard?

KABP® Metaguard is Simple Promise's name for the 50 mg probiotic blend in CardioBiome™, made up of three Lactiplantibacillus plantarum strains - KABP®011, KABP®012, and KABP®013 - that together make up the branded combination studied in the Padro et al. 2024 research as AB-LIFE®.

Is CardioBiome a probiotic?

CardioBiome™ contains a probiotic blend as one of three main components, alongside CoQ10 and artichoke extract - it's not a standalone probiotic product, but a combination formula in which the probiotic strains are positioned as the cardiovascular-research-backed element.

Does CardioBiome contain CoQ10?

Yes. The label lists 100 mg of Coenzyme Q10 (Ubiquinone) per capsule, which the brand describes as a bioavailable form.

How do you take CardioBiome?

Per the brand, one capsule each morning with a glass of water, with no specific food-timing requirement stated. Simple Promise's FAQ emphasizes daily consistency, and recommends 90 to 180 days of continuous use for full effect.

Is CardioBiome a subscription?

No. The accessible product and checkout materials reviewed showed it as a one-time purchase, with no auto-shipments or recurring charges confirmed.

Does CardioBiome have a money-back guarantee?

Yes, a 365-day window from the order date, per the refund policy. Return-shipping payer and carrier requirements aren't specified on the policy page.

What is CardioBiome's shipping timeline?

Per the brand's shipping FAQ, U.S. orders ship free with an estimated 5-7 business day delivery. International orders incur a shipping charge and an estimated 10-14 business-day delivery window, subject to customs; the exact international fee wasn't confirmed in this review.

See CardioBiome's current shipping and pricing details →

Are there CardioBiome customer reviews?

Not yet, as of this article's research. The product page showed zero reviews at the time of review.

Is CardioBiome gluten-free?

Yes, according to the brand. CardioBiome™ is marketed as free of gluten, stimulants, caffeine, and sugar.

Is CardioBiome vegetarian?

Yes, the brand states. The capsule shell is hydroxypropyl methylcellulose, a plant-based material rather than gelatin, consistent with the vegetarian-friendly claim on the label.

Where can CardioBiome be purchased?

Through the official Simple Promise product page, or through this article's tracked promotional link, disclosed as an affiliate relationship at the top of this page.

Is CardioBiome FDA approved?

No. CardioBiome™ is marketed as a dietary supplement, not an FDA-approved drug. Dietary supplements making structure/function claims are not pre-approved by the FDA before sale and must carry the statutory disclaimer.

Can I take CardioBiome alongside other medications?

Simple Promise advises consumers taking blood pressure, cholesterol, or blood-thinning medications to consult a doctor or pharmacist before use. This article echoes that recommendation rather than attempting to assess medication compatibility for individual readers.

See the 365-day guarantee and current pricing →

Buyer Verification Checklist

1. Confirm current pricing and bundle tiers directly on the official product page before ordering.

2. Contact Simple Promise support to confirm return-shipping terms and the exact international shipping charge, if applicable to you.

3. If you take blood pressure, cholesterol, or blood-thinning medication, talk to your doctor or pharmacist before starting CardioBiome™.

4. Review the full Supplement Facts panel on the product page yourself.

5. If the TMAO claim specifically drew your interest, ask your doctor about your own TMAO levels rather than assuming the general marketing claim applies to you.

6. Note your order date, as the 365-day guarantee period is measured from the purchase date.

Get current CardioBiome bundle pricing →

The Bottom Line

CardioBiome™ provides disclosed ingredient amounts, named probiotic strains with published human research, and specific CoQ10 and artichoke quantities rather than a vague proprietary blend.

The main limitation is the gap between some marketing shorthand and the underlying evidence. The TMAO finding, in particular, came from two participants with elevated baseline levels rather than the full study population. The ApoB-related and LDL-particle findings are reported more broadly in the study, but the trial remained small, short, single-arm, and specific to the probiotic strain combination rather than to the finished CardioBiome™ formula.

For consumers interested in the formula, the most useful next step is to compare the current ingredient panel, pricing, guarantee terms, and underlying research against your own goals and healthcare needs before making a purchase decision.

CardioBiome Contact Information

• Brand: Simple Promise™, operated by Simple Promise Pte Ltd

• Phone: 1-800-259-9522 - stated as 24/7 for phone ordering and customer support per Simple Promise's general and product FAQs

• Email: support@mysimplepromise.com

• Mailing address: 3242 NE 3rd Avenue #1051, Camas, WA 98607

• Official site: mysimplepromise.com/products/cardiobiome

• Refund policy: mysimplepromise.com/policies/refund-policy

• Shipping & returns FAQ: mysimplepromise.com/pages/faqs

See current CardioBiome pricing →

Disclosure and Compliance Information

• Material Limitations. This article is based on the official CardioBiome™ product page, ingredients page, refund policy, terms of service, FAQ, and contact page as live-fetched and reviewed in August 2026, plus independent review of the Padro et al. 2024 study in Cardiovascular Research and the Q-SYMBIO trial cited by the brand. No product testing was performed by this publication. Brand claims are attributed and not independently endorsed. Title phrases including "Gut-to-Heart" are brand-originated marketing language. The following could not be confirmed on accessible pages and were omitted or flagged rather than assumed: individual milligram amounts of each KABP® strain within the 50 mg blend; the name or location of the cGMP-certified manufacturing facility; return-shipping payer and carrier requirements under the 365-day guarantee; and the exact international shipping fee.

• Third-Party Feedback Platforms. The accuracy of third-party review platforms referenced or linked from the official site is not endorsed by this publication. Readers should evaluate any customer feedback critically and independently.

• Forward-Looking Statements. This article reflects information available in August 2026. Specifications, pricing, ingredients, and policies are subject to change by the manufacturer without notice. Readers should rely on the brand's official site for current information before ordering.

• Marketing Language Notice. Attribution language throughout this article identifies brand claims as brand claims. Title and body promotional phrases, including "Gut-to-Heart," are brand-asserted marketing language and are not independent rankings, lab-verified claims, or endorsements by this publication.

• California Proposition 65. This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. California buyers should verify the product label and any applicable Proposition 65 warnings published by the manufacturer before purchase.

• Trademark Acknowledgment. CardioBiome™, Simple Promise™, and KABP® are trademarks of their respective owners as used in brand materials reviewed for this article. Registration status was not independently confirmed via USPTO TESS for all marks; trademark symbols are used as presented in the brand's own materials pending that confirmation.

• Geographic and Jurisdiction Notice. This article is intended for a U.S. audience. Product availability, pricing, and applicable regulations may differ outside the United States. International readers should confirm local regulatory status and shipping terms directly with the brand before ordering.

SOURCE: Simple Promise

Source: Simple Promise