Toronto, ON, April 20, 2018 (Newswire.com) - Unlike traditional PCR-based assays, next-generation sequencing (NGS) permits the simultaneous interrogation of multiple disease-causing variants from different variant classes across a multitude of genes. High performance, streamlined target enrichment technologies and workflows are essential to support the routine use of expanded, NGS-based assays in translational and clinical research.
In this Roche-sponsored live webinar, Dr. Oscar Puig, Chief Scientific Officer at Phosphorus will discuss the development of an NGS panel for the detection of genetic variants with direct impact on female and male infertility. The panel, designed for the assessment of sex chromosome aneuploidies, Y chromosome microdeletions and variants in 87 genes (including promoters, 5’- and 3’-untranslated regions, exons and selected introns), is based on optimized SeqCap EZ Prime Choice Probes. Analytical validation was performed using the HyperCap workflow.
Dr. Jennifer Pavlica, Applications Team Manager for the Roche Diagnostics Corporation’s Sequencing and Life Science division will review the HyperCap workflow in more detail. She will outline how the process was streamlined to reduce user intervention and enable end-to-end automation and highlight recommended QC points. The inherent flexibility of this complete, single-vendor target enrichment solution will be demonstrated with key performance data from different inputs and sample types, including FFPE DNA.
Join this complementary event on Thursday, May 10, 2018 at 1pm EDT. For more information about this webinar visit: An NGS Approach for Research on the Genetic Determinants of Female and Male Infertility.
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