Akelos Inc.'s SAB Member Co-Authors Paper Validating HCN1 as a Therapeutic Target for the Treatment of Peripheral Neuropathic Pain
NEW YORK, February 5, 2021 (Newswire.com) - Dr. Peter Goldstein, scientific co-founder of Akelos Inc., a biotechnology company currently developing and commercializing a novel, non-opioid anti-hyperalgesic drug to treat chronic and neuropathic pain, has just co-authored a review article in the peer-reviewed journal Current Neuropharmacology (doi: 10.2174/1570159X19666210119153047. Online ahead of print) that highlights the rationale for targeting HCN1 in sensory neurons for the treatment of peripheral neuropathic pain.
Dr. Goldstein, Professor of Anesthesiology, Professor of Anesthesiology in Neuroscience in the Feil Family Brain and Mind Research Institute, and Associate Professor of Medical Ethics in Medicine at Weill Cornell Medicine (New York, NY) and senior author of the paper, observes: "Novel antihyperalgesics are urgently needed to provide pain relief and minimize disability without the attendant risks of existing therapies. A promising strategy for the development of novel antihyperalgesics is to target ion channels involved in nociception, including the "low-hanging" targets that control peripheral neuronal hyperexcitability. Our work, and that of others, clearly demonstrates that HCN1 channels are indeed such "low-hanging'' fruit."
Akelos Inc. is in a research collaboration with Weill Cornell Medicine to develop and commercialize a novel, non-opioid anti-hyperalgesic drug to treat chronic and neuropathic pain. Dr. Goldstein is a scientific advisory board member of Akelos, Inc.
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Source: Akelos Inc.