Akelos Inc. Identifies Key Aspects Governing Pharmacophore Interactions With Target Site
NEW YORK, February 25, 2019 (Newswire.com) - Akelos Inc., a biotechnology company currently developing and commercializing a novel, non-opioid anti-hyperalgesic drug to treat chronic and neuropathic pain, announces that a research team led by Peter A. Goldstein, MD, a professor of anesthesiology at Weill Cornell Medicine, has identified key structural aspects governing pharmacophore interactions with its molecular target site (HCN1 ion channel).
Using in vitro electrophysiology and kinetic modeling, the research team systematically explored the contribution of ligand architecture to alkylphenol-channel coupling. Their data suggest that a spatially defined cavity that accommodates alkylphenols exists in the transmembrane or interfacial region of the HCN1 ion channel. Such findings support the goal of generating novel high-potency, non-opioid, therapeutics for the treatment of neuropathic pain. These results have been published in Joyce et al. “Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency,” in the peer-reviewed journal Biochemical Pharmacology.
An estimated 20 million people in the United States live with chronic neuropathic pain, for which opioid medication is a common treatment. However, the unprecedented opioid epidemic has made it all the more important to develop new medications that relieve pain without the addictive qualities that can lead to dependency. Our collaboration with Weill Cornell Medicine researchers, led by Dr. Goldstein, is a critical step to realizing that goal.
Dr. Steven Fox, Chairman of Akelos Inc.
Akelos Inc., is in a research collaboration with Weill Cornell Medicine to develop and commercialize a novel, non-opioid anti-hyperalgesic drug to treat chronic and neuropathic pain. The pre-clinical laboratory research that gave rise to Akelos Inc. underlying technology was enabled through prior support provided by Weill Cornell Medicine’s Daedalus Fund for Innovation, an “accelerator” type program that provides gap funding for select research projects at Weill Cornell Medicine with manifest commercial potential. Weill Cornell Medicine’s Office of BioPharma Alliances and Research Collaborations, which leads the Daedalus Fund for Innovation, catalyzed and negotiated the Agreement with Akelos.
Dr. Goldstein, a principal investigator in the C.V. Starr Laboratory of Molecular Neuropharmacology in Weill Cornell Medicine’s Department of Anesthesiology, is a member of the Scientific Advisory Board of Akelos. He also is a named inventor on patents licensed to Akelos and Cornell University.
“An estimated 20 million people in the United States live with chronic neuropathic pain, for which opioid medication is a common treatment,” said Dr. Steven Fox, chairman of Akelos Inc. “However, the unprecedented opioid epidemic has made it all the more important to develop new medications that relieve pain without the addictive qualities that can lead to dependency. Our collaboration with Weill Cornell Medicine researchers, led by Dr. Goldstein, is a critical step to realizing that goal."
Weill Cornell Medicine's Office of BioPharma Alliances and Research Collaborations’ mission is to proactively generate, structure and market translational research alliances with industry in order to advance promising research projects that have commercial potential. For more information, contact Larry Schlossman at las2041@med.cornell.edu or at 212-746-6909.
For more information, please contact:
Akelos Inc.
Dr. Steven Fox, CEO
212-953-1544
drstevefox@aol.com
About Akelos Inc.
Akelos Inc. is a biopharmaceutical clinical company focused on the translation of innovative science into treatment. The company currently is developing novel non-narcotic drugs for the treatment of neuropathic pain. The goal of Akelos is to address some of today’s most pressing areas of unmet needs.
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Source: Akelos Inc.