Letrozole (Femara) by QD Labs
Compared with Aromasin and Arimidex, key competitors, Letrozole (Femara) is 2-5 times more powerful than Anastrozole and Exemestane in the inhibition of the enzyme aromatase, and it is 10-20 times more potent at the cells level.
August 10, 2012 (Newswire.com) - Letrozole (Femara) is a non-specific competitive inhibitors of aromatase.
The drug comes in tablets of 2.5 mg. For a typical dose-dependent effect of Letrozole, so regimen should be clearly calculated. Applied per os is usually one tablet once a day one regardless of the meal, and then rapidly and completely absorbed from the gastrointestinal tract. The degree of its absorption is independent of food intake. The equilibrium concentration in plasma is reached after an average of 4 (from 2 to 6) weeks of application. The drug has no cumulative properties. With plasma proteins, primarily albumin, binds about 60% of letrozole. It penetrates into erythrocytes, where its concentration reaches 80% level in the blood. Letrozole is rapidly and evenly distributed in the tissues.
In terms of how this drug can be used to the benefit of bodybuilders and strength athletes, Letrozole is primarily used to ward any estrogenic side effects caused by the administration of anabolic steroids. Letrozole has been show to have the capability of reducing the level of estrogen in users' bodies by up to 96-98%. This would seemingly be enough in itself to make the compound a desirable one with which steroid users would be interested in. However, Letrozole also has been shown to increase the amount of lutenizing hormone, follicle stimulating hormone, and sex hormone binding globulin in users. When you combine these attributes with the fact that it will help protect against gynocomastia, water retention and other estrogenic side effects Letrozole obviously can fulfill many users' needs.
When initially expressed by existing hepatic dysfunction (raised liver enzymes), the medication should not be given. Side effects are usually mild or moderate and similar to those when taking anastrozole. In addition, 0.6-2% of women taking the drug, there are bloody vaginal discharge, at 1.7% - leucorrhea, and sweating (1.1%), in a small proportion of cases - shortness of breath may develop thrombophlebitis (0 6%). It should be noted that the uncontrolled taking letrozole bodybuilders often leads to disruption of coordination and facilitates the dispersion of attention.
Compared with Aromasin and Arimidex, key competitors, Letrozole (Femara) is 2-5 times more powerful than Anastrozole and Exemestane in the inhibition of the enzyme aromatase, and it is 10-20 times more potent at the cells level! Letrozole is kept for a long time in the body, but some time is needed to get it to work.
Letrozole (Femara) has a half-life (T1 / 2) 2-4 days (!), And the need to take Letrozole (Femara) for 60 days to get a steady level in blood plasma.
The maximum dosage that a user would want to use would be 2.5mgs per day. It has been shown in numerous studies that this dosage will eliminate nearly all of the estrogen in the body in nearly all individuals. Any dose that is higher than this would simply be unneeded. Despite the ability to increase the amount of lutenizing hormone, follicle stimulating hormone, and sex hormone binding globulin in users Letrozole can be counterproductive if used during post-cycle therapy. This is due to the ability of the compound to drive estrogen levels too low during use. Once the substance is discontinued this can result in a "rebound effect" in estrogen levels with these becoming quite high, something that should be avoided during or after post-cycle therapy.
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