The Hazard of Inflammation Associated with Heart Surgery Can Be Reduced with the Help of Omega 3 Fatty Acids
The study suggests that the compounds that are naturally occurring, biologically active, and derived from omega-3 PUFAs reduce inflammation and improve the healing of blood vessels after injury.
Online, July 16, 2013 (Newswire.com) - (http://www.kamagra.biz/):Procedures like stenting, angioplasty, and bypass surgery may save lives, but they also cause excessive scarring and inflammation, which ultimately can lead to permanent disability and even death. Naturally derived compounds from polyunsaturated fatty acids (omega-3s) may reduce the inflammation associated with these procedures to help arteries more fully and completely heal.
The study suggests that the compounds that are naturally occurring, biologically active, and derived from omega-3 PUFAs reduce inflammation and improve the healing of blood vessels after injury. They suggest a new opportunity to improve the long-term results of cardiovascular procedures such as bypass surgery and angioplasty by the therapeutic application of this class of agents or their dietary precursors
They studied the effects of the compounds (resolvin or RvD) first in cultured vascular cells taken from patients who had experienced bypass operations, and then in rabbits and they were treated with a balloon angioplasty procedure in the arteries of the hind limb. In the human cells, treatment with RvD effectively reduced features that are associated with the typical vascular injury response - inflammation, cell growth, and cell migration in vascular smooth muscle cells.
The potency of these compounds corresponds to concentrations that have been measured in the blood of human subjects taking high dose fish oil supplements for short periods of time. In rabbits, they treated the artery with RvD at the time of the balloon angioplasty procedure by infusing the drug directly into the vessel, and established that this one-time treatment reduced inflammation and subsequent scarring of the vessel after one month.
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